Methods for Determination of Molecular Structures

COURSE CURRICULUM

1.

Course title

Methods for determination of molecular structures

2.

Code

HM-704

3.

Study curriculum

All

4.

Organizer of the curriculum (institute, department)

Institute of chemistry, Faculty of Natural Sciences and Mathematics, Skopje

5.

Degree (BSc, MSc, PhD)

BSc

6.

Academic year/semester

IV/VII

7.

ECTS points

4

8.

Lecturer

Full prof. PhD Viktor Stefov

9.

Prerequisites

Instrumental analytical methods, Physical chemistry II

10.

Course objectives (competences):
Understand and gain great knowledge of methods of determining molecular structures as well as solving different problems through analysis of infrared, raman and NMR spectra. 

11.

Course content:

1. Introduction: Spectroscopic methods for determining molecular structures; electromagnetic spectrum.
2. Fundamentals of molecular spectroscopy: rotational spectra; vibrational spectra; rotational-vibrational spectra; Infrared spectroscopy (IR); molecule vibrations; classification of fundamental vibrations; concept of group frequencies; different kinds of group frequencies; factors reagarding group frequencies.
3. Characteristic group frequencies: vibrations of CH₃, CH₂ and CH groups; skeletal C−C vibrations; vibrations of C=О groups; vibrations of other X=Y (X, Y = C, О, N, S) groups; X−Y and vibrations coupled with them;
4. Nuclear magnetic resonance (NMR): introduction; magnetic properties of the nucleus; NMR spectrum; factors affecting the chemical shift; spin-spin coupling; spin-spin coupling mechanism; factors affecting the shielding constant ; ¹³С spectra; spectar-structural correlations of NMR spectroscopy; combined ¹Н and ¹³С spectra; 2D NMR.
5. Combined use of spectroscopic data; finding the simplest chemical formula; Hydrogen defficiency index; combined study of spectral data.

12.

Teaching methods: Lectures, problem solving tasks and laboratory courses

13.

Total available time

120

14.

Time distribution

2+1+1 per week (lectures 30, problem solving tasks 15, laboratory courses 15)

15.

Teaching methods distribution

15.1.

Teaching - lectures

30 lectures

15.2.

Practicals (laboratory, problem solving), seminars, team work

30 lectures

16.

Other activities

16.1.

Projects

16.2.

Independent work

20 lectures

16.3.

Homework

40 lectures

17.

Grading methods

17.1.

Tests

-          Two exams

-          Problem solving tasks and laboratory courses

60 points

25 points

17.2.

Seminars/projects (written/oral presentation)

10 points

17.3.

Activity

5 points

18.

Grading scale (points/mark)

< 50points

5 (five) (F)

From 51 to 60 points

6 (six) (E)

From 61 to 70 points

7 (seven) (D)

From 71 to 80 points

8 (eight) (C)

From 81 to 90 points

9 (nine) (B)

From 91 to 100 points

10 (ten) (A)

19.

Criteria for taking the final exam

Regular attendance and completed laboratory courses

20.

Course language

Macedonian

21.

Teaching quality control

Annonimous questionnaire

22.

Literature

22.1.

Compulsory

No.

Author

Title

Publisher

Year

1.

B. Soptrajanov

Методи за определување на молекулски структури

Internal script

2.

D.L. Pavia, G.M. Lapman, G.S. Kriz

Introduction to spectroscopy

BROOKS/ COLE, CENGAGEGE learning

2009

3.

D. Whittaker

Interpreting organic spectra

The Royal Society of Chemistry

2000

22.2.

Additional

No.

Author

Title

Publisher

Year

1.

R.H Shapiro

Spectral exercises in structural determination of organic compounds

Holt, Rinehart and Winston, Inc.

2.

3.

4.