Chemistry of Natural Products

COURSE CURRICULUM

1.

Course title

CHEMISTRY OF NATURAL PRODUCTS

2.

Code

HМ-823

3.

Study curriculum

All chemistry study programs

4.

Organizer of the curriculum (institute, department)

Institute of chemistry, PMF, UKIM

5.

Degree (BSc, MSc, PhD)

BSc

6.

Academic year/semester

IV/VIII

7.

ECTS points

4

8.

Lecturer

Dr. Natasa Ristovska, Professor
Dr. Jane Bogdanov, Professor

9.

Prerequisites

Organic chemistry II

10.

Course objectives (competences):
The aim of this course is the student to be given detailed view in the field of natural products so that one can improve the knowledge in biology and biochemistry. The student should become able to identify natural products, their biosynthetic origin, application and meaning. The main topic of this subject is the classification of the natural products, their physical and chemical properties and their isolation. The student will be introduced to experimental techniques of isolation and characterization (classical and instrumental) of some natural products.

11.

Course content:
-Introduction to the chemistry of natural products. Primary and secondary metabolites. Origin, role and properties of natural products.
-Classification of secondary metabolites. Determination of carbon skeleton constitution in natural products.
- Overview of key intermediates in the biosynthesis of natural products: acetyl coenzyme A, shikimic acid, mevalonic acid, deoxyxylulose-5-phosphate and amino acids as precursors of peptides, some alkaloids and penicillins.
- Biosynthesis of natural products.
-Overview of different classes of natural products: polyketides and fatty acids, lignins, acetogenins, macrolides, prostaglandins, terpenes and steroids, phenylpropanoids, alkaloids and antibiotics.
-Isolation and physical-chemical properties of natural products.
- Stereochemistry of natural products and their structural determination

12.

Teaching methods: lectures, laboratory classes

13.

Total available time

120 hours

14.

Time distribution

2+0+2 hours/week (lectures 30 hours, laboratory classes 30 hours)

15.

Teaching methods distribution

15.1.

Teaching - lectures

30 hours

15.2.

Practicals (laboratory, problem solving), seminars, team work

30 hours

16.

Other activities

16.1.

Projects

10 hours

16.2.

Independent work

0 hours

16.3.

Homework

50 hours

17.

Grading methods

17.1.

Tests

70 points

17.2.

Seminars/projects (written/oral presentation)

10 points

17.3.

Activity

20 points

18.

Grading scale (points/mark)

< 50 points

5 (five) (F)

51 to 60 points

6 (six) (E)

61 to 70 points

7 (seven) (D)

71 to 80 points

8 (eight) (C)

81 to 90 points

9 (nine) (B)

91 to 100 points

10 (ten) (A)

19.

Criteria for taking the final exam

Finished laboratory practicals and attending lectures

20.

Course language

Macedonian

21.

Teaching quality control

Anonymus surveys for course quality and student suggestions

22.

Literature

22.1.

Compulsory

No.

Author

Title

Publisher

Year

1.

John McMurry

Organic Chemistry 6thed.

Brooks/Cole

2004

2.

Bell C. E.; Taber D. F.; Clark A. K.

Organic chemistry laboratory with qualitative analysis: standard and microscale, 3rd ed.

Thomson

2001

3.

Јане Богданов, Наташа Ристовска

Природни производи (интер­на скрипта од предавања)

2015

22.2.

Additional

No.

Author

Title

Publisher

Year

1.

S. V. Bhat, B. A. Nagasapagi, M. Sivakumar

Chemistry of Natural Products

Narosa, India

2005

2.

Steven P. Stanforth

Natural Product Chemistry at a Glance

Wiley-Blackwell; 1st  ed. Oxford,

2006

3.

Paul M. Dewick

Medicinal Natural Products: A Biosynthetic Approach

John Wiley&Sons

2009

4.