Toxicological Chemistry

COURSE CURRICULUM

1.

Course title

TOXICOLOGICAL CHEMISTRY

2.

Code

HM-653

3.

Study curriculum

All study programs in chemistry

4.

Organizer of the curriculum (institute, department)

Institute of Chemistry, Faculty of Natural Sciences and Mathematics

5.

Degree (BSc, MSc, PhD)

BSc

6.

Academic year/semester

III/VI

7.

ECTS points

4

8.

Lecturer

Prof. Dr. Jasmina Petreska Stanoeva

9.

Prerequisites

Organic chemistry II, Analytical chemistry II

10.

Course objectives (competences):
Students should master the basics of mechanisms of action of toxic substances and their effects on the body.

11.

Course content:
Introduction. Relationship between the dose and the toxic effects of poisons. Characteristics of poison exposures. Types of toxic effects. Interaction with chemical compounds. Factors affecting toxicity. Mechanisms of toxicity. Delivery of the poison. Intoxication and detoxification. Toxic effects due to the disruption of cell functions. Mechanisms of reparation. Resorption, distribution and elimination of poisons. Biotransformation of poisons. Chemical aspects of the first phase of biotransformation of poisons. Biochemical aspects of the first phase of biotransformation of poisons. Reactions in the second phase of biotransformation of poisons. Factors affecting biotransformation. Toxic effects of metals. Toxic metals (arsenic, beryllium, cadmium, chromium, lead, mercury, thallium, barium, antimony, radon), Essential metals with potential toxic effect (copper, zinc, iron, manganese, phosphorus, selenium). Toxic effects of metals in the composition of medicines (silver, mercury, aluminum, gold, boron, calcium, magnesium) , cobalt, copper, fluorine, iron, gadolinium, lithium, platinum, tin, technetium, selenium). Toxic effects of pesticides. Insecticides. Herbicides. Rodenticides. Toxic effects of solvents. Benzene. Alcohols (ethanol, methanol, ethylene glycol). Aliphatic hydrocarbons (hexane, carbon disulfide, dichloromethane, chloroform, carbon tetrachloride). Toxic effects of gases (carbon monoxide, sulfur dioxide, ozone, nitrogen dioxide, hydrocyanic acid, cyanides). 

12.

Teaching methods: lectures, exercises

13.

Total available time

120

14.

Time distribution

2+0+1 hours weekly (lectures: 30 hours;
laboratory classes: 15 hours)

15.

Teaching methods distribution

15.1.

Teaching - lectures

30 hours

15.2.

Practicals (laboratory, problem solving), seminars, team work

15 hours

16.

Other activities

16.1.

Projects

30 hours

16.2.

Independent work

0 hours

16.3.

Homework

45 hours

17.

Grading methods

17.1.

Tests

60 points

17.2.

Seminars/projects (written/oral presentation)

10 points

17.3.

Activity, involvement, grading of lab work

 30 points

18.

Grading scale (points/mark)

< 50 points

5 (five) (F)

51 to 60 points

6 (six) (E)

61 to 70 points

7 (seven) (D)

71 to 80 points

8 (eight) (C)

81 to 90 points

9 (nine) (B)

91 to 100 points

10 (ten) (A)

19.

Criteria for taking the final exam

Attendance at lectures and completed lab exercises

20.

Course language

Macedonian

21.

Teaching quality control

Attendance, colloquiums

22.

Literature

22.1.

Compulsory

No.

Author

Title

Publisher

Year

1.

T. Stafilov

Toxicological chemistry

PMF, Skopje

2005

2.

C. D. Claassen, Editor

Casarett and Doull’s toxicology – The basic science of poisons,  Fifth edition

McGraw-Hill, New York

1996

3.

S. E. Manahan

Environmental chemistry

Lewis Publishers, Boka Raton

2000

22.2.

Additional

No.

Author

Title

Publisher

Year

1.

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