Inorganic Biochemistry

COURSE CURRICULUM

1.

Course title

INORGANIC BIOCHEMISTRY

2.

Code

HM-656

3.

Study curriculum

All study courses at the Institute of Chemistry

4.

Organizer of the curriculum (institute, department)

Institute of Chemistry

5.

Degree (BSc, MSc, PhD)

BSc

6.

Academic year/semester

III/VI

7.

ECTS points

4

8.

Lecturer

Prof. Dr. Biljana Pejova

9.

Prerequisites

Organic chemistry II and Biochemistry I

10.

Course objectives (competences):
The student should gain in-depth knowledge of the chemistry of inorganic compounds relevant to living organisms.

11.

Course content:
1. Introduction: periodic table of bio-elements, essential chemical elements, elements relevant to medicine, metals in biological systems (oxidation states and coordination geometries), classification of bioinorganic systems.
2. Transition elements: occurrence and extraction, physical properties, trends in chemical properties, representative compounds
3. Chemistry of coordination compounds: complex particles, coordination compounds, ligands, polynuclear complexes, nomenclature, coordination polyhedra, structural and optical isomerism, chemical bonding from the perspective of the valence bond theory, crystal field theory, ligand field theory, thermodynamics of complex formation processes.
4. Biological positions for metal coordination: amino acids, nucleic acids, special ligands.
5. Metalloenzymes: acid-base catalysis (enzymes containing zinc, magnesium, iron), enzymes containing cobalt, enzymes relevant to processes involving H₂O₂ and O₂.
6. Metalloproteins: sodium and potassium transport, calcium signaling proteins (calmodulin), zinc in transcription, selective transport and storage of iron (ferritin, siderophores, transferrins), oxygen transport and storage (myoglobin, hemoglobin, hemocyanin, hemeritrin), electron transfer (cytochromes, Fe-S proteins, copper electron transfer centers).
7. Biological cycles: nitrogen cycle, hydrogen cycle.
8. Sensors: proteins containing iron as sensors, proteins that are sensors for Cu and Zn concentrations.
9. Biomineralization
10. Metal complexes in the medical therapy of cancerous diseases

12.

Teaching methods: Lectures and laboratory classes

13.

Total available time

120

14.

Time distribution

2+0+1 hours/week
Lectures 30 hours
Lab classes 15 hours

15.

Teaching methods distribution

15.1.

Teaching - lectures

30 hours

15.2.

Practicals (laboratory, problem solving), seminars, team work

15 hours

16.

Other activities

16.1.

Projects

15 hours

16.2.

Independent work

30 hours

16.3.

Homework

30 hours

17.

Grading methods

17.1.

Tests

90 points

17.2.

Seminars/projects (written/oral presentation)

0 points

17.3.

Activity

10 points

18.

Grading scale (points/mark)

< 50 points

5 (five) (F)

51 to 60 points

6 (six) (E)

61 to 70 points

7 (seven) (D)

71 to 80 points

8 (eight) (C)

81 to 90 points

9 (nine) (B)

91 to 100 points

10 (ten) (A)

19.

Criteria for taking the final exam

Attendance at lectures and completed lab classes

20.

Course language

Macedonian, English

21.

Teaching quality control

Anonymous surveys, discussions with students

22.

Literature

22.1.

Compulsory

No.

Author

Title

Publisher

Year

1.

J. J. Frausto da Silva, R. J. P. Williams

The biological chemistry of the elements

Oxford University press

2001

2.

Duward Shriver, Peter Atkins

Inorganic Chemistry

Mikena, Bitola

2010

3.

Rosette M. Roat-Malone

Bioinorganic chemistry

Wiley

2007

22.2.

Additional

No.

Author

Title

Publisher

Year

1.

2.

3.

4.