Biochemistry I

COURSE CURRICULUM

1.

Course title

BIOCHEMISTRY I

2.

Code

HМ-505

3.

Study curriculum

All chemistry study programs

4.

Organizer of the curriculum (institute, department)

Institute of chemistry, PMF, UKIM

5.

Degree (BSc, MSc, PhD)

BSc

6.

Academic year/semester

III/V

7.

ECTS points

8

8.

Lecturer

Dr. Natasa Ristovska, Professor
Dr. Jane Bogdanov, Professor
Dr. Emil Popovski, Professor

9.

Prerequisites

Organic chemistry I

10.

Course objectives (competences):
Through teaching and exercises, students should master the basics of biochemistry, acquire theoretical knowledge and practical experience, as a prerequisite for successfully following the teaching of higher courses in biochemistry and other biochemical disciplines. In this way, students will begin to professionally train as biochemists.

11.

Course content:
-Introduction to biochemistry: pH, biochemical buffers.
-Carbohydrates: Definition. Physical traits and division. Monosaccharides. Carbohydrate derivatives. Oligosaccharides. Polysaccharides. More important representatives of carbohydrates.
-Lipids and membranes: Higher fatty acids. Acylglycerols. Glycerolphospholipids. Sphingolipids. Steroids and carotenoids. Cholesterol. Bile acids. Steroid glycosides. Biological membranes. Transport across membranes.
-Amino acids, peptides and proteins: Important amino acids. Chemical properties of amino acids. Peptides. Proteins. Definition, physical and chemical properties of proteins. Biological function of proteins. Important representatives of different classes of proteins: fibrillar, globular, nucleoproteins, chromoproteins, glycoproteins, phosphoproteins, lipoproteins.
-Vitamins and coenzymes: Role of vitamins and coenzymes. Division of vitamins. Water soluble vitamins. Oil soluble vitamins.
-Enzymes and enzyme action: Chemical nature of enzymes. Specificity of enzyme action. Types of enzyme catalysis. Chemical kinetics of enzymatic reactions. Michaelis-Menten kinetics.
-Nucleic acids: Chemical properties of nucleic acids. Deoxyribonucleic acid - DNA. Chemical synthesis of DNA. DNA hybridization. Ribonucleic acids – RNA. Types and properties of RNA.

12.

Teaching methods: lectures, laboratory classes, problem solving, projects

13.

Total available time

240 hours

14.

Time distribution

4+1+3 hours/week (lectures 60 hours, problem solving 15 hours, laboratory classes 45 hours)

15.

Teaching methods distribution

15.1.

Teaching - lectures

60 hours

15.2.

Practicals (laboratory, problem solving), seminars, team work

60 hours

16.

Other activities

16.1.

Projects

10 hours

16.2.

Independent work

20 hours

16.3.

Homework

90 hours

17.

Grading methods

17.1.

Tests

80 points

17.2.

Seminars/projects (written/oral presentation)

5 points

17.3.

Activity

15 points

18.

Grading scale (points/mark)

< 50 points

5 (five) (F)

51 to 60 points

6 (six) (E)

61 to 70 points

7 (seven) (D)

71 to 80 points

8 (eight) (C)

81 to 90 points

9 (nine) (B)

91 to 100 points

10 (ten) (A)

19.

Criteria for taking the final exam

Finished laboratory practicals and attending lectures

20.

Course language

Macedonian

21.

Teaching quality control

Anonymus surveys for course quality and student suggestions

22.

Literature

22.1.

Compulsory

No.

Author

Title

Publisher

Year

1.

Nelson, D. L. Cox, M. M Кокс

Lehninger, Principles of Biochemistry

НИП Микена

2011

2.

John McMurry

Organic Chemistry 6thed.

Brooks/Cole

2004

3.

Џекова, С. и соработници

Биохемија

2001

22.2.

Additional

No.

Author

Title

Publisher

Year

1.

Garrett, R.H., Grisham, C.M.

Biochemistry, 4th Ed.

Brooks Cole

2008

2.

Mathews,C.K., VanHolde,K.E., Ahern, K.G.

Biochemistry 3rd Ed.

Prentice Hall

2000

3.

4.