Biochemistry II

COURSE CURRICULUM

1.

Course title

BIOCHEMISTRY II

2.

Code

HМ-605

3.

Study curriculum

All chemistry study programs

4.

Organizer of the curriculum (institute, department)

Institute of chemistry, PMF, UKIM

5.

Degree (BSc, MSc, PhD)

BSc

6.

Academic year/semester

III/VI

7.

ECTS points

6

8.

Lecturer

Dr. Natasa Ristovska, Professor
Dr. Slobotka Aleksovska, Professor
Dr. Valentin Mirceski, Professor

9.

Prerequisites

Organic chemistry II

10.

Course objectives (competences):
Through teaching and exercises, students should continue to upgrade their knowledge from the basic biochemistry course. In this course, students will learn about the pathways of metabolism of biomolecules, their breakdown and synthesis in the body. The lectures and exercises will enable the students to get a general picture of the way the organism functions, constant dynamic processing, synthesis and decomposition of substances and they will be able to predict them.

11.

Course content:
Metabolism of substances. Basic characteristics of control mechanisms of metabolism. Types of organic reactions in metabolism. Physico-chemical characteristics of metabolic reactions. Metabolism of carbohydrates. Anaerobic breakdown of carbohydrates. Aerobic breakdown of carbohydrates. Krebs cycle. Breathing chain. Pentose-phosphate cycle. Biosynthesis of carbohydrates. Photosynthesis. Control of carbohydrate metabolism. Physico-chemical control, thermodynamic characteristics and other mechanisms of control. Lipid metabolism. Formation of acetoacetic acid. Biosynthesis of fatty acids and fats. Metabolism of phosphatides. Metabolism of cholesterol and bile acids. Relationship with other metabolic processes. Control of lipid metabolism. Metabolism of proteins and amino acids. Synthesis of amino acids. Formation of urea. Oxidative decarboxylation. Metabolism of individual amino acids. Breakdown of proteins. Mechanism of some important chemical reactions in protein metabolism. Relationship with other metabolic processes. Physico-chemical control, thermodynamic characteristics and other mechanisms of control.

12.

Teaching methods: lectures, laboratory classes, problem solving, projects

13.

Total available time

180 hours

14.

Time distribution

3+0+3 hours/week (lectures 45 hours, , laboratory classes 45 hours)

15.

Teaching methods distribution

15.1.

Teaching - lectures

45 hours

15.2.

Practicals (laboratory, problem solving), seminars, team work

45 hours

16.

Other activities

16.1.

Projects

15 hours

16.2.

Independent work

15 hours

16.3.

Homework

60 hours

17.

Grading methods

17.1.

Tests

70 points

17.2.

Seminars/projects (written/oral presentation)

10 points

17.3.

Activity

20 points

18.

Grading scale (points/mark)

< 50 points

5 (five) (F)

51 to 60 points

6 (six) (E)

61 to 70 points

7 (seven) (D)

71 to 80 points

8 (eight) (C)

81 to 90 points

9 (nine) (B)

91 to 100 points

10 (ten) (A)

19.

Criteria for taking the final exam

Finished laboratory practicals and attending lectures

20.

Course language

Macedonian

21.

Teaching quality control

Anonymus surveys for course quality and student suggestions

22.

Literature

22.1.

Compulsory

No.

Author

Title

Publisher

Year

1.

Nelson, D. L. Cox, M. M Кокс

Lehninger, Principles of Biochemistry

НИП Микена

2011

2.

Џекова, С. и соработници

Биохемија

2001

3.

22.2.

Additional

No.

Author

Title

Publisher

Year

1.

Garrett, R.H., Grisham, C.M.

Biochemistry, 4th Ed.

Brooks Cole

2008

2.

Mathews,C.K., VanHolde,K.E., Ahern, K.G.

Biochemistry 3rd Ed.

Prentice Hall

2000

3.

Berg, J.M., Tymoczko, J.L., Stryer, L.

Biochemistry, 5th Ed.

W.H.Freeman and Co.

2002

4.